Cerebral lesions produced in healthy dogs by the intravenous injection of 4:4′-diamidino stilbene

Selective central nervous system lesions of a constant type are described in dogs after the intravenous injection of freshly prepared 1 per cent. aqueous solution of 4:4′-diamidino stilbene. In most of the animals these lesions were associated with definite and characteristic neurological signs which occurred during the course of injections. It is suggested that these experimental lesions may throw some light on the pathogenesis of certain neuropathic signs and symptoms described after the use of the drug in man.