Oral Administration of Solubilized Amphotericin B

THE intravenous administration of the solubilized preparation of amphotericin B has proved to be an effective means of treating systemic fungal infections in man.1 , 2 This route of administration, however, is frequently attended by severe generalized reactions and localized irritation or frank phlebitis so that necessary long-term therapy may be difficult or impossible.Oral administration of the drug, employing nonsolubilized amphotericin B, has been tried, but this preparation has proved of limited value in systemic mycoses in man.3 Recently, Campbell and Hill4 have shown that the solubilized preparation for intravenous use, when given orally in drinking water, protected mice with experimental . . .