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June 4, 2013CirculationOpen Access

Early Trpm7 deletion causes congestive heart failure and death by embryonic day 11.5; late deletion produces viable mice with normal adult ventricular function; intermediate deletion results in 50% developing cardiomyopathy associated with heart block, impaired repolarization, and ventricular arrhythmias.

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Population

Cardiac-targeted knockout mice

Design

Preclinical

Authors

RSRajan SahPMPietro MesircaXMXenos Mason

Discussion

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Overview

Trpm7 dispensable in adult myocardium; leaves open its role in human developmental cardiomyopathy or arrhythmias.

Structured PICO

P
Population
Cardiac-targeted knockout mice
I
Intervention
Trpm7 deletion at early (before embryonic day 9), intermediate, or late (about embryonic day 13) stages of cardiogenesis
O
Outcome
Ventricular function, conduction, repolarization, and survivalsurrogate

Trpm7 is critical for myocardial proliferation during early cardiogenesis, and its loss at intermediate developmental stages impairs adult ventricular function, conduction, and repolarization, though it is dispensable in adult myocardium under basal conditions.

Cite This Study

Sah et al. (2013) studied this question.

synapsesocial.com/papers/6a866317ae12ed54832fe1e8https://doi.org/10.1161/circulationaha.112.000768
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Deletion of <i>Trpm4</i> alters the function and expression of Na <sub>V</sub> 1.5 channel in murine cardiac myocytes2020
  2. 2Deletion of Trpm4 Alters the Function of the Nav1.5 Channel in Murine Cardiac Myocytes2021 · 25 citations
  3. 3TRPM7 Deficiency Protects Against Myocardial Ischemia-Reperfusion Injury by Regulating Intracellular Zn <sup>2+</sup> Homeostasis2026 · 1 citations
  4. 4The TRPM4 mutation p.I377T is a direct cause of electrophysiological alterations and increases arrhythmia sensitivity in mouse cardiac muscle2026
  5. 5Knockdown of the TRPM4 channel alters cardiac electrophysiology and hemodynamics in a sex- and age-dependent manner in mice2022