MiRP1 acts as a beta subunit for the HCN family, suggesting it regulates both inward and outward channels underlying cardiac pacemaker activity.
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Hypothesis-generating for pacemaker mechanisms in animals; leaves open clinical relevance to human arrhythmias.
The HCN family of ion channel subunits underlies the currents I(f) in heart and I(h) and I(q) in the nervous system. In the present study, we demonstrate that minK-related peptide 1 (MiRP1) is a beta subunit for the HCN family. As such, it enhances protein and current expression as well as accelerating the kinetics of activation. Because MiRP1 also functions as a beta subunit for the cardiac delayed rectifier I(Kr), these results suggest that this peptide may have the unique role of regulating both the inward and outward channels that underlie cardiac pacemaker activity. The full text of this article is available at http://www.circresaha.org.
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Yu et al. (2001) studied this question.
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