Why the study?
Does MiRP1 modulate the gating function of Kv4.2 and Kv4.3 channels in a Xenopus oocyte expression system?
Population
Xenopus oocyte expression system
Comparison
Co-expression of minK-related peptide 1 with… vs Kv4.x channels expressed alone
Design
Preclinical
Authors
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MiRP1 modulation of Kv4.2 in oocytes supports its candidacy as an I(to) beta subunit; leaves open physiologic relevance in native human myocytes.
Does MiRP1 modulate the gating function of Kv4.2 and Kv4.3 channels in a Xenopus oocyte expression system?
MiRP1 associates with Kv4.2 and modulates its gating function, suggesting it may serve as a regulatory beta subunit of transient outward (I(to)) channels in the heart.
Zhang et al. (2001) studied this question.
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