Population
Murine cardiac myocytes and a clonal cell line (tsA201) expressing human MiRP3, Kv4.2, and KChIP2
Comparison
Expression of MiRP3 and/or KChIP2 with Kv4.2 vs Kv4.2 alone or different combinations of the…
Design
Preclinical
Authors
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MiRP3-KChIP2 effects on Ito remain hypothesis-generating in animals; leaves open any role in human regional repolarization or arrhythmia risk.
MiRP3 and KChIP2 co-assemble with Kv4.2 to modulate cardiac transient outward potassium currents, suggesting that regional heterogeneity in these subunits may determine local I(to) properties.
Lévy et al. (2010) studied this question.
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