Population
Human and canine left ventricle tissues, and cells expressing hKv4.3 current
Design
Preclinical
Authors
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KChIP2 unlikely sole Ito gradient mediator; leaves open Ca2+-dependent splice variant roles in native myocytes.
KChIP2 splice variants differentially modulate hKv4.3 current in a Ca2+-dependent manner, but the lack of a transmural protein gradient suggests it may not be a requisite component of ventricular I(to) or is modified by other factors.
Deschênes et al. (2002) studied this question.
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