Key result
Coexpression of fKChIP2 isoforms with Kv4.3 produced a fourfold acceleration of recovery kinetics compared to Kv4.3 expressed alone, with fKChIP2a shifting steady-state activation.
Population
Ferret heart (ventricles) and Xenopus oocytes
Comparison
Coexpression of Kv4.3 and ferret KChIP2 isoforms vs Kv4.3 expressed alone
Design
Preclinical
Authors
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KChIP2 isoforms accelerate Kv4.3 recovery in ferret cells; leaves open their role and need for cofactors in native human Ito.
Ferret KChIP2 isoforms modulate Kv4.3 channel recovery kinetics, suggesting their involvement in generating the native rapidly recovering cardiac transient outward current, though additional regulatory factors are likely required.
Patel et al. (2002) studied this question. fKChIP2 isoforms coexpressed with Kv4.3 vs. Kv4.3 expressed alone was evaluated on Recovery kinetics. Coexpression of fKChIP2 isoforms with Kv4.3 produced a fourfold acceleration of recovery kinetics compared to Kv4.3 expressed alone, with fKChIP2a shifting steady-state activation.
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