Alpha 1-adrenergic stimulation with phenylephrine induces dose-dependent magnesium release in perfused rat livers.
No immediate clinical implications for magnesium management; leaves open the role of alpha1-adrenergic signaling in human hepatic Mg2+ homeostasis.
The possibility that Mg2+ mobilization is stimulated in perfused liver by alpha 1-adrenergic agonists was studied by measuring Mg2+ release in response to 0.5 and 20 microM phenylephrine. During preperfusion exogenous Mg2+ was added to the medium to give 1.2 mM. 5 min before starting the addition of phenylephrine the infusion of exogenous Mg2+ was stopped. Mg2+ in the perfusate leaving the liver was measured by atomic absorption spectroscopy. Analysis of the Mg2+ decay curves with two exponential models indicated that phenylephrine caused dose-dependent Mg2+ release from perfused rat livers.
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Jakob et al. (1989) studied this question.
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