This study provides the first evidence of core+1/ARF protein expression in the context of a JFH1-based replicon, identifying two distinct isoforms.
Hepatitis C virus contains a second open reading frame within the core gene, designated core+1/ARF. Here we demonstrate for the first time expression of core+1/ARF protein in the context of a bicistronic JFH1-based replicon and report the production of two isoforms, core+1/L (long) and core+1/S (short), with different kinetics.
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Kotta‐Loizou et al. (2015) studied this question.
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