Vincristine Sulfate Therapy in Children With Metastatic Soft Tissue Sarcoma

Sixteen children with metastatic or recurrent lesions from soft tissue sarcoma, mostly rhabdomyosarcoma, were treated with vincristine sulfate in a protocol-controlled cooperative study. Complete, though not permanent, regression of tumor occurred in two patients. Significant partial control of disease was achieved in three other children. Gastrointestinal or neurologic side-effects resulted in alteration of drug dosage schedule in 4 of 15 patients. The degree of antitumor activity in several of these cases was such that the further study of the effectiveness of the drug, particularly in combination with surgical and radiation therapy, in children with soft tissue sarcoma seems indicated. Generic and trade names of drugs: vincristine sulfate—Oncovin; cyclophosphamide—Cytoxan; chlorambucil—Leukeran; dactinomycin—Actinomycin-D.