Population
45 individuals with spinal muscular atrophy (SMA) types II and III
Design
Cohort
Follow-up
10 years
Authors
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May inform prognostic counseling in SMA II versus III; leaves open relevance of minor ECG abnormalities.
SMA type II is associated with progressive weakness, scoliosis, and restrictive lung disease, whereas type III has a more static course, though both feature substantial disability and frequent minor ECG abnormalities.
Carter et al. (1995) studied this question.
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