January 1, 1993Biochemical JournalOpen Access

Deglycosylation and fragmentation of purified rat liver angiotensin II receptor: application to the mapping of hormone-binding domains

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Population

Purified rat liver angiotensin II receptor (AT1 subclass)

Design

Preclinical

Authors

FDFranck DésarnaudInserm JMJacky MarieÉcole Nationale Supérieure de Chimie de Montpellier CLColette LombardCentre National de la Recherche Scientifique

Discussion

Member takes

Implication

Supports AT1 receptor domain mapping in rodents; leaves open translation to human binding or therapeutics.

Structured PICO

Population

Purified rat liver angiotensin II receptor (AT1 subclass)

Intervention

Chemical or enzymic deglycosylation and fragmentation with V8 protease, CNBr, and trypsin

Outcome

Structural characterization and mapping of hormone-binding domains

The study provides structural data supporting that the third transmembrane domain and adjacent loops of the rat AT1 receptor are involved in binding the C-terminal of angiotensin II.

Cite This Study

Désarnaud et al. (1993) studied this question.

synapsesocial.com/papers/6a866744cdff5daddc73b28f https://doi.org/10.1042/bj2890289

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Deglycosylation and fragmentation of purified rat liver angiotensin II receptor: application to the mapping of hormone-binding domains

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Deglycosylation and fragmentation of purified rat liver angiotensin II receptor: application to the mapping of hormone-binding domains

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider