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Summary: The growth of several adenine-independent strains of yeasts in defined media containing suboptimal concentrations of biotin and relatively high concentrations of methionine is associated with the formation of a pink pigment in the cells and of an arylamine in the culture fluid. Under similar conditions, pigment and arylamine are not produced by an adenine-requiring strain of Schizosaccharomyces octosporus. Culture filtrates containing arylamine promote the growth of Sch. octosporus in adenine-free medium, but an adenine-requiring lactobacillus responds only after a considerable lag. The results are interpreted to mean that the arylamine is, or is derived from, a precursor of adenine, whose conversion to adenine is impaired by deficiency of biotin.
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Chamberlain et al. (1952) studied this question.
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