Ultrastructural differences observed in Paracoccidioides brasiliensis yeast phase cells grown on solid and in liquid medium

An ultrastructural study was conducted on, yeast-like Paracoccidioides brasiliensis cells grown on liquid and solid peptone--yeast extract--glucose medium. A large proportion of cells grown in liquid medium presented cytoplasmic damage compared with the cells grown on solid medium, which remained intact, suggesting that agar plays an important role in the development of this fungus.