Why the study?
Does glucosamine and chondroitin improve analgesic and structural effects in osteoarthritis?
Does glucosamine and chondroitin improve analgesic and structural effects in osteoarthritis?
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The author critiques the trial selection criteria in a meta-analysis of glucosamine and chondroitin for osteoarthritis.
The results and interpretation of the meta-analysis by Wandel and colleagues of the effects of glucosamine and chondroitin on osteoarthritis depend on the trials analysed and the thresholds defined as clinically relevant.1 The criteria for the selection of trials is questionable; the European Medicines Agency recommends evaluating the analgesic effect of slow acting drugs for osteoarthritis after at least six months of treatment, and the structural effect after two years. …
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Pelletier et al. (2010) studied this question.
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