Why the study?
Does magnesium sulfate improve perioperative analgesia and reduce anesthetic use in surgical patients?
Does magnesium sulfate improve perioperative analgesia and reduce anesthetic use in surgical patients?
Magnesium sulfate is highlighted as a versatile and cost-effective adjunct in anesthesiology with anesthetic- and analgesic-sparing properties.
May support adjunctive use but should not change practice; leaves open confirmation in prospective RCTs.
Magnesium sulfate has been used in preeclampsia patients in order to prevent seizure. It is also used for the treatment of arrhythmia and asthma and as an anesthetic adjunct in patients undergoing surgery for pheochromocytoma. However, its potentiating effects on perioperative analgesia and muscle relaxation have drawn attention recently. These characteristics of magnesium (anesthetic- and analgesic-sparing effect) enable anesthesiologists to reduce the use of anesthetics during surgery and the use of analgesics after surgery. Magnesium sulfate has a high therapeutic index and cost-effectiveness. Considering these diverse characteristics useful for anesthesia, appropriate use of magnesium sulfate would improve surgical outcome and patients' satisfaction.
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Sang-Hwan Do (2013) studied this question.
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