What question did this study set out to answer?

To determine whether the rs7903146 T risk allele in the TCF7L2 gene elevates type 2 diabetes risk by altering real-time in vivo insulin synthesis and beta cell function.

March 30, 2018EBioMedicineOpen Access

Transcription factor 7-like 2 gene links increased in vivo insulin synthesis to type 2 diabetes

View Full Paper

Ask AI

Bookmark

Authors

SJSjaam JainandunsingMaasstad Ziekenhuis HKH. Rita KooleErasmus MC JMJoram N.I. van MiertErasmus MC

Discussion

Member takes

Implication

Family study reveals increased insulin synthesis linked to TCF7L2 risk alleles in diabetic individuals, suggesting hyperinsulinemia directly drives type 2 diabetes pathogenesis.

Key Points

To determine whether the rs7903146 T risk allele in the TCF7L2 gene elevates type 2 diabetes risk by altering real-time in vivo insulin synthesis and beta cell function.
Conducted a family-based study comparing individuals with type 2 diabetes to unaffected relatives.
Measured real-time insulin synthesis using stable isotopes during an oral glucose tolerance test.
Calculated insulin sensitivity and beta cell function indices using oral minimal model analyses.
Individuals with type 2 diabetes exhibited lower oral minimal model indices and higher insulin synthesis rates than unaffected relatives.
A T-allele dosage effect was observed, with diabetic T-allele carriers displaying significantly higher insulin synthesis than wild-type individuals.

Cite This Study

Jainandunsing et al. (2018) studied this question.

synapsesocial.com/papers/6a866acc40931805045afcda https://doi.org/10.1016/j.ebiom.2018.03.026

View Full Paper

Ask AI

Bookmark

Implication

Family study reveals increased insulin synthesis linked to TCF7L2 risk alleles in diabetic individuals, suggesting hyperinsulinemia directly drives type 2 diabetes pathogenesis.

Transcription factor 7-like 2 gene links increased in vivo insulin synthesis to type 2 diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

Transcription factor 7-like 2 gene links increased in vivo insulin synthesis to type 2 diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider