Baseline Presence of NAFLD Predicts Weight Loss after Gastric Bypass Surgery for Morbid Obesity

Figures

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  Figure 1. Study flowchart. Study flowchart showing amount of patients assessed for eligibility, number of patients not enrolled and allocation according to histopathology and the number of patients in the three populations (no NAFLD, NAFL and NASH). Allocation was performed by using the histological NAFLD activity score from the NASH-CRN. Abbreviations: NAFLD—Non-alcoholic fatty liver disease; NAFL—Non-alcoholic fatty liver; NASH—Non-alcoholic steatohepatitis; NASH-CRN—Nonalcoholic Steatohepatitis Clinical Research Network Study Group.

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  Figure 2. Histological stainings and APRI Representative hematoxylin and eosin stainings (A) of patients in the “No NAFLD”, “NAFL” and “NASH” group. No NAFLD is characterized by absence of relevant steatosis, ballooning, inflammatory reaction. NAFL patients showed modest steatosis, ballooning, and inflammatory reaction. NASH patients showed severe steatosis, ballooning, inflammation. Slides are captured at a 100x magnification, scale bars are 200 µm. Graph showing APRI for “No NAFLD”, “NAFL” and “NASH” (B). Data are expressed as mean ± standard error of the mean (SEM). p-values for comparisons with the “NASH” group are provided above the bar. Abbreviations: NAFLD—non-alcoholic fatty liver disease; NAFL—non-alcoholic fatty liver; NASH—non-alcoholic steatohepatitis; APRI—AST-to-platelet ratio index.

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  Figure 3. Evolution of weight loss, BMI loss, %TBWL and %EWL. Diagrams showing the evolution of BMI (A), BMI loss (B), %TBWL (C) and %EWL (D) at baseline and after 3, 6 and 12 months postoperatively for “No NAFLD”, “NAFL” and “NASH” patients. Data are plotted as medians. p-values within the graph were computed for the six months follow-up visit by Kruskal–Wallis test. Abbreviations: BMI—body mass index; %TBWL—percentage of total body weight loss; %EWL—percentage of excessive weight loss.