Why the study?
Does atorvastatin 80 mg once daily improve cognition and memory in individuals with mild-to-moderate Alzheimer's disease?
Population
Individuals with mild-to-moderate Alzheimer's disease, with allowed stable use of cholinesterase inhibitors…
Comparison
Atorvastatin 80 mg once daily for 1 year. vs Placebo.
Design
RCT, 1:1, double-blind, placebo-controlled
Follow-up
1 year
Authors
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Supports atorvastatin for cognitive benefit in mild-to-moderate Alzheimer's; extends statin evaluation to neurodegenerative disease.
Does atorvastatin 80 mg once daily improve cognition and memory in individuals with mild-to-moderate Alzheimer's disease?
Atorvastatin 80 mg daily may improve cognitive performance in patients with mild-to-moderate Alzheimer's disease, particularly when initiated earlier in the disease course.
Sparks et al. (2006) studied this question.
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