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March 27, 2014Toxicological Sciences

An Integrated Characterization of Serological, Pathological, and Functional Events in Doxorubicin-Induced Cardiotoxicity

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Population

Hannover Wistar rats

Design

Preclinical

Follow-up

12 weeks

Authors

LCLaura Cove-SmithThe Christie HospitalNWNeil WoodhouseHeidenhain (United Kingdom)AHAdam HargreavesUniversity College London

Discussion

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Overview

Early subcellular/MRI changes precede clinical doxorubicin cardiotoxicity in rats; hypothesis-generating for human surveillance before practice change.

Structured PICO

P
Population
Hannover Wistar rats
I
Intervention
Doxorubicin 1.25 mg/kg weekly for 8 weeks followed by a 4-week off-dosing recovery period
O
Outcome
Timecourse of serological, pathological, and functional events (including MRI indices, histopathology, and cTnI)surrogate

In a rat model of doxorubicin-induced cardiotoxicity, subcellular and functional changes detectable by MRI precede serological biomarker elevations and clinical heart failure.

Cite This Study

Cove-Smith et al. (2014) studied this question.

synapsesocial.com/papers/6a86720fcdff5daddc73b5f7https://doi.org/10.1093/toxsci/kfu057
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Also Consider

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  1. 1Effects of In Vitro and In Vivo Exposure to Doxorubicin (Adriamycin) on Caffeine-Induced Ca2+ Release from Sarcoplasmic Reticulum and Contractile Protein Function in ‘Chemically-Skinned’ Rabbit Ventricular Trabeculae1998 · 29 citations
  2. 2Cardiac Diastolic Function in Pediatric Patients Receiving Doxorubicin1994 · 34 citations
  3. 3Activation of nuclear factor-κB during doxorubicin-induced apoptosis in endothelial cells and myocytes is pro-apoptotic: the role of hydrogen peroxide2002 · 293 citations
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  5. 5Troponin Release—Reversible or Irreversible Injury? Should We Care?2011 · 77 citations