Why the study?
Does fondaparinux reduce peritoneal fibrosis and angiogenesis in a rat model of chlorhexidine gluconate-induced peritoneal fibrosis?
Population
Wistar rats with peritoneal fibrosis induced by daily intraperitoneal injection of chlorhexidine gluconate
Comparison
Factor Xa inhibitor fondaparinux administered… vs Normal group and CG-injected group without…
Design
Preclinical
Follow-up
28 days
Authors
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Hypothesis-generating for factor Xa inhibition in peritoneal fibrosis; requires clinical trials before any practice consideration.
Does fondaparinux reduce peritoneal fibrosis and angiogenesis in a rat model of chlorhexidine gluconate-induced peritoneal fibrosis?
Factor Xa inhibition with fondaparinux reduces peritoneal fibrosis and angiogenesis in a rat model, suggesting a role for the coagulation cascade in peritoneal fibrosis.
Saito et al. (2009) studied this question.
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