Population
Polyethylene capillaries lined with a confluent layer of human umbilical vein endothelial cells (HUVECs)
Comparison
Perfusion with tumor necrosis factor, factor X… vs Extracellular matrix preparations, absence of…
Design
Preclinical
Authors
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Does not alter anticoagulation practice; extends in vitro TFPI mechanism insights but leaves open in vivo validation.
In an in vitro capillary model, TFPI-mediated neutralization of endothelial cell and matrix tissue factor activity requires the presence of factor VIIa in addition to factor Xa.
Lindhout et al. (1992) studied this question.
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