Cultured human umbilical vein endothelial cells constitutively produce the higher molecular weight form of extrinsic pathway inhibitor, which is largely unaffected by short-term induction of tissue factor activity.
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Endothelial EPI data warrant no practice change; leaves open in vivo regulation and therapeutic targeting of TFPI.
Warn‐Cramer et al. (1989) studied this question.
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