HUVECs express functional high-affinity receptors for factor Xa related to EPR-1, which mediate intracellular signaling, mitogenesis, and prothrombin activation, highlighting its role in vascular wall homeostasis.
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Hypothesis-generating for factor Xa in endothelial mitogenesis and coagulation; leaves open in vivo relevance for vascular disease.
Bono et al. (1997) studied this question.
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