December 1, 1983Journal of Clinical InvestigationOpen Access

Regulation of factor Xa in vitro in human and mouse plasma and in vivo in mouse. Role of the endothelium and plasma proteinase inhibitors.

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Population

Human and mouse plasma (in vitro) and mice (in vivo)

Design

Preclinical

Follow-up

up to 15 minutes

Authors

HFH E FuchsDuke University SPSalvatore V. PizzoDuke University

Discussion

Member takes

Implication

In vitro Factor Xa binding may mislead; leaves open endothelial modulation of coagulation in vivo.

Structured PICO

Population

Human and mouse plasma (in vitro) and mice (in vivo)

Intervention

125I-Factor Xa or diisopropylphosphoryl-Factor Xa

Outcome

Factor Xa binding to proteinase inhibitors and plasma clearancesurrogate

In vivo, Factor Xa binds to specific thrombin-binding sites on endothelial cells, which alters its proteinase inhibitor specificity compared to in vitro conditions.

Cite This Study

Fuchs et al. (1983) studied this question.

synapsesocial.com/papers/6a82bb1284489985200f67d7 https://doi.org/10.1172/jci111169

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Regulation of factor Xa in vitro in human and mouse plasma and in vivo in mouse. Role of the endothelium and plasma proteinase inhibitors.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of factor Xa in vitro in human and mouse plasma and in vivo in mouse. Role of the endothelium and plasma proteinase inhibitors.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider