April 16, 2009Haemostasis

Antifactor Xa Activity Measured with Amidolytic Methods

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Population

Plasma samples (clinical material and plasma with antithrombin III removed by immunoadsorption)

Authors

OØO.R. ØdegårdOslo University Hospital MLM. LieThe Affiliated Yongchuan Hospital of Chongqing Medical University UAUlrich AbildgaardCross-Cutting Cardiology

Discussion

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Implication

Amidolytic antifactor Xa assays may reflect antithrombin III activity in heparinized plasma; leaves open added clinical value beyond standard ATIII assays.

Structured PICO

Population

Plasma samples (clinical material and plasma with antithrombin III removed by immunoadsorption)

Intervention

Measurement of antifactor Xa activity using amidolytic methods (with bovine activated factor X and chromogene substrate Bz-Ile-Glu-Gly-Arg-pNA) in the presence and absence of heparin

Outcome

Correlation of Xa-inactivating capacity to thrombin-inactivating capacity (heparin cofactor activity)surrogate

Amidolytic methods can effectively measure antifactor Xa activity in plasma, reflecting antithrombin III concentration, without significant interference from fibrinogen or its degradation products.

Cite This Study

Ødegård et al. (2009) studied this question.

synapsesocial.com/papers/6a8ff0b133cf5c591c0d2c04 https://doi.org/10.1159/000214145

View Full Paper

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Implication

Amidolytic antifactor Xa assays may reflect antithrombin III activity in heparinized plasma; leaves open added clinical value beyond standard ATIII assays.

Antifactor Xa Activity Measured with Amidolytic Methods

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Antifactor Xa Activity Measured with Amidolytic Methods

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider