Why the study?
Does active site-blocked factor Xa (Xai) prevent thrombus formation in a canine coronary thrombosis model?
Population
Canine coronary thrombosis model
Comparison
Intravenous bolus of bovine… vs Intravenous bolus of saline, Factor X, or heparin
Design
Preclinical
Authors
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Xai antithrombotic efficacy in canines is hypothesis-generating; leaves open human translation given bleeding signals in this model.
Does active site-blocked factor Xa (Xai) prevent thrombus formation in a canine coronary thrombosis model?
In a canine model, active site-blocked factor Xa (Xai) effectively prevents coronary thrombus formation but simultaneously increases extravascular bleeding tendency.
Benedict et al. (1993) studied this question.
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