Why the study?
Does FXV673 improve carotid artery blood flow and reduce thrombus mass compared to heparin or placebo in a canine model of arterial thrombosis?
Population
Conscious dogs instrumented surgically to induce carotid artery thrombosis by electrolytic injury (n=24)
Comparison
FXV673 100 microg/kg bolus + 10 microg/kg/min… vs Heparin or placebo for 3 hours on days 1 and 2
Design
Preclinical
Follow-up
5 days
Authors
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Reduces thrombus more than heparin in canine model; leaves open translation to human arterial thrombosis.
Does FXV673 improve carotid artery blood flow and reduce thrombus mass compared to heparin or placebo in a canine model of arterial thrombosis?
Short-term infusion of the direct factor Xa inhibitor FXV673 provides superior long-term antithrombotic efficacy and arterial passivation compared to standard heparin in a canine thrombosis model.
Rebello et al. (2001) studied this question.
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