Why the study?
Does a synthetic protein C activation peptide inhibit thrombin-induced platelet aggregation in platelets from healthy individuals?
Does a synthetic protein C activation peptide inhibit thrombin-induced platelet aggregation in platelets from healthy individuals?
A synthetic peptide mimicking the protein C activation peptide inhibits thrombin-induced platelet aggregation and calcium mobilization, suggesting interaction with a platelet membrane receptor.
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Should not change antiplatelet practice; hypothesis-generating for protein C peptide analogs in thrombosis models.
The peptide NH(2)-DTEDQEDQVDPR-COOH is released during activation of protein C zymogen. We measured the effect of a synthetic peptide with an amino acid sequence similar to that of the natural peptide on platelets from healthy individuals using platelet aggregometry. We found that this synthetic peptide inhibits platelet aggregation induced by thrombin; furthermore, it diminishes mobilization of intraplatelet calcium. Molecular docking showed weak interaction between the synthetic peptide and thrombin. Our findings suggest that this synthetic peptide may interact with a receptor located on the platelet cell membrane.
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Canseco et al. (2007) studied this question.
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