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Does the pattern of reversed diastolic blood flow on duplex ultrasonography predict graft loss in renal allografts with dysfunction?
Does the pattern of reversed diastolic blood flow on duplex ultrasonography predict graft loss in renal allografts with dysfunction?
The specific pattern of reversed diastolic blood flow on duplex ultrasonography can help prognosticate graft survival in renal allografts with dysfunction.
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May stratify graft loss risk by reversed flow pattern on duplex US in dysfunctional renal allografts; leaves open validation before clinical use.
In 25 renal allografts out of 253 with graft dysfunction a reversed diastolic blood flow was observed at duplex ultrasonography during the first post-transplant month. Eleven grafts were lost and 14 survived. The cause of graft loss was arterial thrombosis (n=1), venous thrombosis or obstruction (n=4), steroid resistant acute rejection (n=4) and acute tubular necrosis (ATN) (n=2). The cause of graft dysfunction in the surviving grafts was ATN (n=7) and acute allograft rejection (n=7). Grafts with only peak-like or low velocity continuous diastolic flow reversal had a better prognosis (3 out of 15 were lost) than grafts with any other type of reversed flow pattern (8 out of 10 were lost). This difference was statistically significant (p<0.01).
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Saarinen et al. (1994) studied this question.
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