Why the study?
Does interferon β-1a compared to interferon β-1b improve cytokine profiles and clinical outcomes in patients with relapsing-remitting multiple sclerosis?
Does interferon β-1a compared to interferon β-1b improve cytokine profiles and clinical outcomes in patients with relapsing-remitting multiple sclerosis?
Long-term interferon β monotherapy in RRMS patients improves clinical indices and reduces serum nitrite levels, suggesting a link to nitric oxide-mediated pathways rather than cytokine levels.
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IFNβ monotherapy was associated with lower nitrite and better RRMS outcomes; leaves open mechanistic role of nitric oxide pathways.
Stępień et al. (2013) studied this question.
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