Decreased nephron population resulting from increased ureteral pressure

The glucose Tm and GFR were determined for each kidney in anesthetized dogs. After three control periods a hydrostatic pressure was applied to one ureter. This resulted in a decrease in GFR over all ranges of ureteral pressures. Tm glucose remained essentially unchanged until the ureteral pressure was elevated to more than 30% of mean blood pressure. At ureteral pressures greater than this, Tm glucose was significantly depressed. The data were used in an attempt to calculate the range and the mean glomerular capillary pressure.