July 1, 1983AJP Renal Physiology

Angiotensin in the hemodynamic response to chronic nephron obstruction

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Why the study?

Does angiotensin blockade or renin suppression improve glomerular blood flow in chronically obstructed nephrons in rats?

Structured PICO

Does angiotensin blockade or renin suppression improve glomerular blood flow in chronically obstructed nephrons in rats?

Population

Rats with 24-h tubular obstruction (n=34)

Intervention

Pharmacologic interruption of angiotensin activity (captopril 10 mg/kg orally or saralasin 10 micrograms/kg/min i.v.) or renin suppression (high salt intake and deoxycorticosterone injections)

Comparator

Control rats with normal and oil-blocked superficial cortical nephrons

Outcome

Glomerular blood flow (GBF) and nephron vascular resistancesurrogate

Pharmacologic interruption of angiotensin activity or renin suppression improves glomerular blood flow in obstructed nephrons, supporting angiotensin's role as a local factor controlling glomerular hemodynamics.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Captopril improves glomerular blood flow in obstructed rat nephrons; leaves open translation to human obstructive nephropathy.

Cite This Study

Carmines et al. (1983) studied this question.

synapsesocial.com/papers/6a867600db42350baa3a62ab https://doi.org/10.1152/ajprenal.1983.245.1.f75

View Full Paper

Ask AI

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Angiotensin in the hemodynamic response to chronic nephron obstruction

Structured PICO

Discussion

Implication

Cite This Study

Angiotensin in the hemodynamic response to chronic nephron obstruction

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider