We have previously described the inhibitory effect of interferon preparations on the multiplication of L1210 cells in vitro and presented the experimental results suggesting that interferon itself was the responsible factor (3, 4, 6) . This inhibition could be due to a decrease in the number of cells capable of dividing, to a prolongation of the cell generation time, to a decrease in the doubling potential of each cell between subcultivation and the stationary phase, or to a combination of these effects . We present here the results of experiments designed to test each of these possibilities by analyzing the effect of interferon on the division cycle of L1210 cells .
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Macieira‐Coelho et al. (1971) studied this question.
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