Population
Cells infected with encephalomyocarditis virus (EMCV), parechovirus 1 (ParV1), and echovirus 11 (EV11)
Design
Preclinical
Authors
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Differential picornavirus COPI dependence may inform selective antivirals; leaves open translation from animal models to therapy.
Different picornaviruses have varying requirements for COPI in the formation of their replication complexes, which correlates with their sensitivity to Brefeldin A.
Gazina et al. (2002) studied this question.
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