Why the study?
Does acute hypoglycemia decrease myocardial blood flow reserve in patients with type 1 diabetes mellitus and healthy humans?
Population
47 volunteers, comprising 28 patients with type 1 diabetes mellitus and 19 healthy control subjects.
Comparison
Hyperinsulinemic clamps with sequential… vs Baseline state and hyperinsulinemic euglycemia…
Design
Other
Follow-up
60 minutes per clamp phase
Authors
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Hypoglycemia may heighten CV risk via impaired perfusion; hypothesis-generating and should not yet change T1DM targets.
Does acute hypoglycemia decrease myocardial blood flow reserve in patients with type 1 diabetes mellitus and healthy humans?
Acute hypoglycemia significantly decreases myocardial blood flow reserve, providing a potential physiological mechanism for the association between hypoglycemia and increased cardiovascular mortality.
Byrne et al. (2011) studied this question.
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