Why the study?
What are the mechanisms of resetting reentrant circuits in canine ventricular tachycardia?
What are the mechanisms of resetting reentrant circuits in canine ventricular tachycardia?
Resetting of reentrant circuits in ventricular tachycardia is caused by multiple mechanisms including interval-dependent conduction delay and concealed retrograde penetration.
Answers are grounded in this paper and cite their sources.
Does not alter human VT management; extends reentry mechanism insights in animal models.
BACKGROUND: Resetting has been used to characterize reentrant circuits causing clinical tachycardias. METHODS AND RESULTS: To determine the mechanisms of resetting, sustained ventricular tachycardia was induced in dogs with 4-day-old myocardial infarctions by programmed stimulation. Premature stimulation was accomplished from multiple regions within reentrant circuits; resetting curves were constructed and compared with activation maps. Monotonically increasing responses, or a "mixed" response (increasing portion preceded by a flat portion), occurred. All reentrant circuits had a fully excitable gap. Interval-dependent conduction delay and concealed retrograde penetration led to increased resetting response curves. CONCLUSIONS: Multiple mechanisms revealed by mapping cause resetting of reentrant circuits.
No takes yet. Share an insight, caveat, or question.
Hanna et al. (2001) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: