Why the study?
While the role of platelets in hemostasis and thrombosis is established, their contributions extend to innate and adaptive immune functions during infection and inflammation.
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Design
Comprehensive review
Platelets' immune roles may shape infection outcomes; extends their scope beyond thrombosis but leaves clinical translation open.
Platelets have long been recognized for their role in maintaining the balance between hemostasis and thrombosis. While their contributions to blood clotting have been well established, it has been increasingly evident that their roles extend to both innate and adaptive immune functions during infection and inflammation. In this comprehensive review, we describe the various ways in which platelets interact with different microbes and elicit immune responses either directly, or through modulation of leukocyte behaviors.
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Gautam et al. (2020) studied this question.
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