December 1, 2002Molecular TherapyOpen Access

Intraarticular Gene Transfer of TNFR:Fc Suppresses Experimental Arthritis with Reduced Systemic Distribution of the Gene Product

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Why the study?

Does rAAV-mediated gene transfer of TNFR:Fc suppress arthritis in a rat model?

Structured PICO

Does rAAV-mediated gene transfer of TNFR:Fc suppress arthritis in a rat model?

Population

Streptococcal cell wall (SCW)-induced rat arthritis model

Intervention

Recombinant adeno-associated virus (rAAV) vector encoding rat TNF receptor-immunoglobulin Fc (TNFR:Fc) fusion gene, administered locally (intraarticular) or systemically (intramuscular)

Outcome

Development and severity of arthritis (inflammatory cell infiltration, pannus formation, cartilage and bone destruction, mRNA expression of joint proinflammatory cytokines)surrogate

Intraarticular delivery of rAAV-TNFR:Fc effectively suppresses experimental arthritis while minimizing systemic exposure to the gene product.

Discussion

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Implication

Should not alter clinical arthritis management; leaves open translation of localized rAAV gene therapy to human trials.

Cite This Study

Chan et al. (2002) studied this question.

synapsesocial.com/papers/6a86865cbc357473c2a98c67 https://doi.org/10.1006/mthe.2002.0808

View Full Paper

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Intraarticular Gene Transfer of TNFR:Fc Suppresses Experimental Arthritis with Reduced Systemic Distribution of the Gene Product

Structured PICO

Discussion

Implication

Cite This Study

Intraarticular Gene Transfer of TNFR:Fc Suppresses Experimental Arthritis with Reduced Systemic Distribution of the Gene Product

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider