The nucleolus, the site of ribosomal RNA synthesis, provides us with one of the best opportunities for unravelling the relationships between transcription and the spatial organization of chromatin. Some of the best visualizations of the transcription process have come from nucleolar spread preparations (Miller, 1981) but this procedure introduces major structural reorganizations that deny us a molecular interpretation of the intact nucleolus.
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E. G. Jordan (1991) studied this question.
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