PRELIMINARY WORK in this laboratory has shown that the injection of FSH into adult laying hens causes the growth of many follicles which may be made to ovulate following intravenous injection of LH. Fraps and Riley (1942) found similar results with PMS pretreatment followed by LH. Injections of gonadotropes, when given in sufficiently high dosages, usually cause cessation of laying within a few days after the first injection (Bates, Lahr and Riddle 1935). Pretreatment with FSH and the administration of LH will permit the ovulation of 2-8 follicles per hen (Nalbandov unpublished) or on the average about 3.5 ovulations per hen (see also Fraps and Riley 1942). As a follow-up to the studies on the laying hen it was of interest to determine the effect of the FSH-LH combination upon the resting or intermittently functioning ovary of the adult hen. It is also of theoretical and of practical importance to determine whether the inactive ovary of the adult hen is comparable, in its ability to respond to gonadotropes, to the inactive ovary of the immature chick. Some studies have been reported on the effect of various gonadotropes on the immature chicken ovary.
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Nalbandov et al. (1946) studied this question.