LAWRENCE and Riddle (1916) reported that lipids of the blood are increased in the fowl during the egg-laying season. This finding was confirmed by Lorenz,. Entenman and Chaikoff (1938), who showed, that in birds actively engaged in egg-laying there is a marked but variable increase in the levels of triglycerides, phospholipids and free cholesterol of the blood. Since the rise in blood lipids was observed first in the pubescent female containing ova in the rapid growth stage, but at no time from early age to past maturity was detectable in the male bird, these workers concluded that ovarian activity is involved in these lipid changes. This conclusion was upheld in later experiments (Entenman, Lorenz and Chaikoff, 1938) in which it was shown that injections of pregnant-mare serum, which contains a gonad-stimulating principle, led to a rise in the levels of all the blood-lipid constituents of the immature female bird.
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Taurog et al. (1944) studied this question.