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The iridoids of Harpagophytum procumbens and Harpagophytum zeyheri were studied by CLHP. Harpagoside is the main iridoid for both drugs whereas 8- p -coumaroylharpagide is a representative iridoid of Harpagophytum zeyheri only. The ratio harpagoside/8- p -coumaroylharpagide can be used to distinguish chemically both species. For commercial dried aqueous extracts this ratio is intermediate because they are probably prepared from a mixture of H. procumbens and H. zeyheri drugs. The aqueous extracts of both drugs show similar analgesic and anti-inflammatory properties. Harpagophytum procumbens and Harpagophytum zeyheri should be accepted as sources for the drug Harpagophyti radix. key words Harpagophytum procumbens - Harpagophytum zeyheri - Pedaliaceae - harpagoside - 8- p -coumaroylharpagide - anti-inflammatory activity - analgesic activity
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Baghdikian et al. (1997) studied this question.
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