What question did this study set out to answer?

To determine the therapeutic efficacy and optimal timing of ganciclovir and cidofovir administration in a murine model of cytomegalovirus-induced myocarditis.

May 1, 2001Antimicrobial Agents and ChemotherapyOpen Access

Ganciclovir and Cidofovir Treatment of Cytomegalovirus-Induced Myocarditis in Mice

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Why the study?

Does ganciclovir or cidofovir reduce the severity of cytomegalovirus-induced myocarditis in a murine model?

Population

Adult BALB/c mice infected with Murine CMV (MCMV)

Comparison

Ganciclovir or cidofovir vs No treatment or delayed treatment (implied)

Design

Preclinical

Authors

JLJason C. LenzoHarry Perkins Institute of Medical Research GSGeoffrey ShellamThe Kids Research Institute Australia CLC M LawsonMurdoch University

Discussion

Member takes

Implication

Early antiviral timing effects in murine CMV myocarditis should not alter practice; leaves open human translation and optimal windows.

Key Points

To determine the therapeutic efficacy and optimal timing of ganciclovir and cidofovir administration in a murine model of cytomegalovirus-induced myocarditis.
Inoculated adult BALB/c mice with murine cytomegalovirus (MCMV) to model acute and chronic phases of human viral myocarditis.
Administered ganciclovir or cidofovir beginning at 24 hours post-infection, after the acute phase, or during viral reinfection.
Treatment initiated 24 hours post-infection significantly reduced acute myocardial inflammation and diminished the severity of subsequent chronic myocarditis.
Antiviral administration initiated after the acute phase produced no observable reduction in chronic myocarditis severity.
Ganciclovir and cidofovir prevented reinfection-induced exacerbations of myocardial inflammation, although preexisting myocardial necrosis and damage remained unchanged.

Structured PICO

Does ganciclovir or cidofovir reduce the severity of cytomegalovirus-induced myocarditis in a murine model?

Population

Adult BALB/c mice infected with Murine CMV (MCMV)

Intervention

Ganciclovir or cidofovir

Comparator

No treatment or delayed treatment (implied)

Outcome

Severity of acute and chronic phases of myocarditis (inflammation and necrosis)surrogate

Early administration of ganciclovir or cidofovir attenuates acute and chronic MCMV-induced myocarditis in mice, highlighting the importance of early antiviral therapy.

Cite This Study

Lenzo et al. (2001) studied this question.

synapsesocial.com/papers/6a868b90a0f68bd200d0a2aa https://doi.org/10.1128/aac.45.5.1444-1449.2001

Topics

Myocarditis

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Ganciclovir and Cidofovir Treatment of Cytomegalovirus-Induced Myocarditis in Mice

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Ganciclovir and Cidofovir Treatment of Cytomegalovirus-Induced Myocarditis in Mice

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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