Why the study?
Succinate sensor GPR91 is present on platelets, but the molecular mechanisms and potential involvement of eicosanoids in succinate-enhanced platelet activation and aggregation remain to be deciphered.
Succinate enhances platelet aggregation and proinflammatory leukotriene biosynthesis via the GPR91 receptor, identifying a potential novel target for atherothrombotic diseases.
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Succinate-GPR91 signaling may enhance platelet activation via eicosanoids; leaves open any role in atherothrombosis pending clinical studies.
Tang et al. (2020) studied this question.
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