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September 28, 1999CirculationOpen Access

Evidence for Prothrombotic Effects of Exercise and Limited Protection by Aspirin

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Why the study?

Does aspirin pretreatment prevent the prothrombotic effects of exhaustive exercise in healthy men?

Population

15 healthy men

Comparison

1 week of pretreatment with aspirin prior to… vs Exhaustive exercise without aspirin pretreatment

Design

Other

Follow-up

1 week

Authors

NLNailin LiKarolinska University HospitalNWN. Håkan WallénKarolinska InstitutetPHPaul HjemdahlPreventive Cardiology

Discussion

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Implication

Aspirin does not blunt exercise-induced platelet aggregates in healthy men; leaves open relevance to patients at thrombotic risk.

Structured PICO

Does aspirin pretreatment prevent the prothrombotic effects of exhaustive exercise in healthy men?

P
Population
15 healthy men
I
Intervention
1 week of pretreatment with aspirin (500 mg/day) prior to exhaustive exercise
C
Comparator
Exhaustive exercise without aspirin pretreatment
O
Outcome
Platelet aggregability, platelet and leukocyte activation, and platelet-leukocyte aggregates measured before and immediately after exercisesurrogate

Aspirin pretreatment (500 mg/day) does not prevent the acute prothrombotic effects of exhaustive exercise in healthy men.

Cite This Study

Li et al. (1999) studied this question.

synapsesocial.com/papers/6a725e3626a7f98052de424chttps://doi.org/10.1161/01.cir.100.13.1374

Topics

Dual antiplatelet therapy
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