Why the study?
Does flow cytometry for CD62 and CD63 expression predict impending thrombus formation?
Does flow cytometry for CD62 and CD63 expression predict impending thrombus formation?
Flow cytometry for platelet expression of CD62 and CD63 may be a valuable tool in predicting impending thrombus formation.
May support prospective evaluation of CD62/CD63 flow cytometry for thrombosis risk; leaves open clinical utility from Level 5 evidence.
A large right atrial mass was discovered in a 16-year-old female patient receiving chemotherapy treatment for Hodgkin disease. The patient was participating in a platelet function research study. During laboratory examination of platelet activation, increasing CD62 and CD63 expression were found to mirror the clot formation. Further investigation of platelet expression of CD62 and CD63 by flow cytometry might reveal it to be a valuable tool in predicting impending thrombus formation.
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Saving et al. (2003) studied this question.
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