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March 1, 2006Pharmacogenetics and Genomics

Identification of a novel specific CYP2B6 allele in Africans causing impaired metabolism of the HIV drug efavirenz

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Authors

JWJue WangRoche (Switzerland)ASAnders SönnerborgKarolinska University HospitalARAnders RaneAgios Pharmaceuticals (United States)

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Wang et al. (2006) studied this question.

synapsesocial.com/papers/6a86901d8db6a14f9375e4d2https://doi.org/10.1097/01.fpc.0000189797.03845.90
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Population pharmacokinetics and effects of efavirenz in patients with human immunodeficiency virus infection2003 · 267 citations
  2. 2A novel human cytochrome P4S0 gene (P450IIB): chromosomal localization and evidence for alternative splicing1988 · 57 citations
  3. 3Characterisation and PCR‐based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population1999 · 206 citations
  4. 4Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B62003 · 250 citations