Why the study?
WPW syndrome predisposes patients to life-threatening tachyarrhythmias, and malignant arrhythmias may occur unexpectedly even in previously asymptomatic individuals.
Answers are grounded in this paper and cite their sources.
This case highlights the risk of rapid progression from antidromic AVRT to ventricular fibrillation in WPW syndrome, emphasizing the need for prompt electrical cardioversion and catheter ablation.
BACKGROUND: Wolff-Parkinson-White (WPW) syndrome predisposes patients to life-threatening tachyarrhythmias due to rapid ventricular activation via an accessory pathway. Malignant arrhythmias may occur unexpectedly, even in previously asymptomatic individuals. CASE SUMMARY: A 36-year-old man presented with sudden palpitations and a regular wide-complex tachycardia consistent with antidromic atrioventricular reentrant tachycardia. The rhythm rapidly deteriorated into preexcited atrial fibrillation and progressed to ventricular fibrillation cardiac arrest requiring immediate defibrillation and cardiopulmonary resuscitation, with successful return of spontaneous circulation. Postresuscitation electrocardiography demonstrated persistent ventricular preexcitation. Electrophysiological study subsequently confirmed a left lateral accessory pathway, and successful radiofrequency catheter ablation resulted in complete resolution of ventricular preexcitation. DISCUSSION: This case highlights the malignant electrophysiological behavior of WPW and the diagnostic and therapeutic challenges of wide-complex tachycardia, particularly in resource-limited settings. TAKE-HOME MESSAGES: WPW may rapidly progress from antidromic atrioventricular reentrant tachycardia to ventricular fibrillation. Early recognition, prompt electrical cardioversion/defibrillation, and timely referral for catheter ablation are critical.
No takes yet. Share an insight, caveat, or question.
Rahman et al. (2026) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: